The formula to calculate the Accumulation Ratio (Rac) is:
\[ Rac = \frac{AUC_{ss}}{AUC_{1}} \]
Where:
The Accumulation Ratio (Rac) is a measure used in pharmacokinetics to determine the extent to which a drug accumulates in the body after multiple doses. It is calculated by dividing the area under the curve (AUC) during single dose steady state by the AUC during a dose interval after one single dose. This ratio helps in understanding the drug's behavior and its potential for accumulation over time.
Let's assume the following values:
Using the formula to calculate the Accumulation Ratio (Rac):
\[ Rac = \frac{500}{250} = 2 \]
The Accumulation Ratio (Rac) is 2.