Limit of Detection Calculator

Formula

To calculate the Limit of Detection (\(LOD\)):

\[ LOD = 3.3 \times \frac{Sy}{S} \]

Where:

\(LOD\) is the Limit of Detection
\(Sy\) is the Standard Deviation of the Response Curve
\(S\) is the Standard Deviation of the Calibration Curve

What is Limit of Detection?

A limit of detection is a term used in chemistry to describe the lowest concentration or quantity of a component that can be reliably detected with an analytical method.

Example Calculation 1

Let's assume the following values:

Standard Deviation of Response Curve (\(Sy\)) = 0.02
Standard Deviation of Calibration Curve (\(S\)) = 0.01

Using the formula:

\[ LOD = 3.3 \times \frac{0.02}{0.01} = 6.6 \]

The Limit of Detection is 6.6.

Example Calculation 2

Let's assume the following values:

Standard Deviation of Response Curve (\(Sy\)) = 0.05
Standard Deviation of Calibration Curve (\(S\)) = 0.02

Using the formula:

\[ LOD = 3.3 \times \frac{0.05}{0.02} = 8.25 \]

The Limit of Detection is 8.25.