The formula to calculate the Hydrodynamic Radius (Rh) is:
\[ \text{Rh} = \left( \frac{3 \cdot \text{MW}}{4 \cdot \pi \cdot \text{f}} \right)^{\frac{1}{3}} \]
Where:
The hydrodynamic radius is a parameter that describes the size of a molecule in solution. It is the radius of a hard sphere that diffuses at the same rate as the molecule of interest. For proteins, the hydrodynamic radius can provide insights into the protein’s tertiary and quaternary structure and is important for understanding protein behavior in different environments.
Let's assume the following values:
Using the formula to calculate the Hydrodynamic Radius:
\[ \text{Rh} = \left( \frac{3 \cdot 50000}{4 \cdot \pi \cdot 1.2} \right)^{\frac{1}{3}} \approx 21.5 \text{ nm} \]
The Hydrodynamic Radius (Rh) is approximately 21.5 nm.