Maddrey Score Calculator

Formula

To calculate the Maddrey Score ( $MS$ ):

$MS = 4.6 \times (PT - \text{control PT}) + \text{serum bilirubin level}$

Where:

$MS$ is the Maddrey Score
$PT$ is the Prothrombin Time (seconds)
$\text{control PT}$ is the Control Prothrombin Time (seconds)
$\text{serum bilirubin level}$ is the Serum Bilirubin Level (mg/dL)

What is the Maddrey Score?

The Maddrey Discriminant Function, commonly known as the Maddrey Score, is a clinical tool used to assess the severity and prognosis of alcoholic hepatitis, a form of liver inflammation caused by excessive alcohol consumption. It is calculated using the patient’s prothrombin time (or international normalized ratio, INR) and serum bilirubin level. A score equal to or greater than 32 indicates severe alcoholic hepatitis and is associated with a high mortality rate, suggesting the potential need for corticosteroid therapy or other forms of treatment to reduce inflammation and support liver function.

Example Calculation

Let's assume the following values:

Prothrombin Time ( $PT$ ) = 20 seconds
Control Prothrombin Time ( $\text{control PT}$ ) = 12 seconds
Serum Bilirubin Level ( $\text{serum bilirubin level}$ ) = 5 mg/dL

Using the formula:

$MS = 4.6 \times (20 - 12) + 5 \approx 41.8$

The Maddrey Score is approximately 41.8, indicating severe alcoholic hepatitis.